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Ghostface is on the loose — again and again and AGAIN!

The “Scream” franchise began in 1996 with the late great Wes Craven at the helm, chronicling notorious killer Ghostface as they terrorized high school students and murdered classmates in the small town of Woodsboro.

The man (or woman) donning the mask reminiscent of artist Edvard Munch’s 1893 painting “The Scream” is often someone connected to their victims.

With six “Scream” flicks and more in the works, the horror franchise has been in theaters for more than 25 years and its legacy has forever become a staple of the spooky season.

Main character Sidney Prescott (Neve Campbell) has been at the center of Ghostface’s murder spree for much of the series, but every time she almost always comes out unscathed as the ultimate Final Girl.

While there are a lot of killers in the series to keep track of, this handy guide will keep you straight.

Keep reading to learn about every murderer in the franchise.

Warning: Spoilers ahead for the “Scream” movies. Read at your own risk …

‘Scream’ (1996)

Billy Loomis (Skeet Ulrich) was Sidney’s boyfriend for the first flick and is the original Ghostface. But by the third act of “Scream,” he reveals himself and pal Stu Macher (Matthew Lillard) to be the homicidal maniacs behind the mask.

They first murdered Sidney’s mother, Maureen Prescott, a year before their killing spree started as retaliation for Billy’s father having an affair with Maureen and causing his parents’ divorce.

Billy and Stu’s kill count is six, as they also slashed friends Casey Becker (Drew Barrymore), Tatum Riley (Rose McGowan) and more.

But, of course, by the end, the men are killed by Sidney.